Difference Between Dmg And Iso
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- Difference Between Dmg And Iso
| Names | |
|---|---|
| IUPAC name | |
| Other names N,N-Dimethylglycine | |
| Identifiers | |
| |
| 3DMet | |
| 1700261 | |
| ChEBI | |
| ChemSpider |
|
| DrugBank | |
| ECHA InfoCard | 100.012.971 |
| EC Number |
|
| 82215 | |
| KEGG |
|
| MeSH | dimethylglycine |
| RTECS number | |
CompTox Dashboard(EPA) | |
| |
| |
| Properties | |
| C4H9NO2 | |
| Molar mass | 103.121 g·mol−1 |
| Appearance | White crystals |
| Odor | Odourless |
| Density | 1.069 g/mL |
| Melting point | 178 to 182 °C (352 to 360 °F; 451 to 455 K) |
| Boiling point | 175.2 °C (347.4 °F; 448.3 K) |
| Hazards | |
| GHS pictograms | |
| GHS Signal word | Warning |
| H302 | |
| Lethal dose or concentration (LD, LC): | |
| >650 mg kg−1(oral, rat) | |
| Related compounds | |
Related alkanoic acids | |
| Dimethylacetamide | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
Dimethylglycine (DMG) is a derivative of the amino acidglycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline.
When DMG was first discovered, it was referred to as Vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects and it is synthesized by the human body in the citric acid (or Krebs) cycle meaning it does not meet the definition of a vitamin.
Uses[edit]
Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease.[2] There is no evidence that dimethylglycine is effective for treating mitochondrial disease.[3] Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.[4][5]
Biological activity[edit]
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Dimethylglycine has been found to act as an agonist of the glycine site of the NMDA receptor.[6]
Preparation[edit]
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This compound is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may have been obtained by neutralization of the acid salt, which has been performed with silver oxide.[7]
Assess gank opportunities better. You should average 70-80 CS per 10 minutes of game when laning, substract 2 minutes for short games (there are no minions in lane until 2mins), and around 50 CS per 10 when jungling.The reason you feel useful as a tank is that tanks' buildpaths are much cheaper than carries' buildpaths, so you're still useful (though you would be more useful with more gold and items, you don't feel it as much.)on your OP.GG you can see cs per minute just to the right of your total cs, you average around 3 in the jungle and around 4 in lane. It should be around 7-8 when laning and around 4-5 for junglers. Hypixel how to deal a lot of dmg. Obviously it can be lower on heavy roaming or ganking champions, as long as you're making up for the lost cs in pressure and team advantage, and as much as possible your roams and ganks need to bring YOU as much gold as the cs you missed would have.
- H2NCH2COOH + 2 CH2O + 2 HCOOH → (CH3)2NCH2COOH + 2 CO2 + 2 H2O
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References[edit]
- ^'dimethylglycine - Compound Summary'. PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. Identification. Retrieved 24 April 2012.
- ^'Dimethylglycine'. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. December 8, 2009.
- ^Pfeffer, Gerald; Majamaa, Kari; Turnbull, Douglass M.; Thorburn, David; Chinnery, Patrick F. (2012-04-18). 'Treatment for mitochondrial disorders'. The Cochrane Database of Systematic Reviews (4): CD004426. doi:10.1002/14651858.CD004426.pub3. ISSN1469-493X. PMID22513923.
- ^Bolman WM, Richmond JA (June 1999). 'A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder'. Journal of Autism and Developmental Disorders. 29 (3): 191–4. doi:10.1023/A:1023023820671. PMID10425581.
- ^Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). 'Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder'. Journal of Child Neurology. 16 (3): 169–73. doi:10.1177/088307380101600303. PMID11305684.
- ^Lin, Jen-Cheng; Chan, Ming-Huan; Lee, Mei-Yi; Chen, Yi-Chyan; Chen, Hwei-Hsien (2016). 'N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice'. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 71: 7–13. doi:10.1016/j.pnpbp.2016.06.002. ISSN0278-5846. PMID27296677.
- ^Clarke, H. T.; Gillespie, H. B.; Weisshaus, S. Z. (1933). 'The Action of Formaldehyde on Amines and Amino Acids'. Journal of the American Chemical Society. 55 (11): 4571. doi:10.1021/ja01338a041.